劍橋大學基因學部

By詹啟敏
University of Cambridge-Department of Genetics
Models of human development PSCs 


Laboratory of this group is interested in how cells build embryos. The approach this question by asking cells, specifically Embryonic Stem Cells (ESCs) how much can they do on their own. His group work with mammalian ESCs because over the last decade advances in the ability to grow them and differentiate them in dishes and wells have opened up exciting experimental possibilities which are exploiting. In these endeavours, this group don’t forget the embryo which is, perhaps not the teacher that Viktor Hamburger anointed it as in his famous sentence, but a reference for our work.

A few years ago, this aboratory saw that under defined culture conditions mouse ESCs could be coaxed into 3D aggregates that would form structures with a good representation of the vertebrate body plan.  These structures called ‘gastruloids’ because what they create mirrors the outcome of gastrulation.

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